Adaptive changes in the 5-HT2 binding site after chronic administration of agonists and antagonists

  title={Adaptive changes in the 5-HT2 binding site after chronic administration of agonists and antagonists},
  author={M. A. Blackshear and L. Martin and E. sanders-Bush},
  • M. A. Blackshear, L. Martin, E. sanders-Bush
  • Published 1986
  • Biology, Medicine
  • Neuropharmacology
  • This study confirms and extends an earlier report that acute administration of the serotonin (5-HT) antagonist, mianserin, caused a marked decrease in the density of 5-HT2 binding sites in brain of the rat (Blackshear and Sanders-Bush, 1982). Using [3H]ketanserin, a selective ligand for the 5-HT2 site, the present study further investigated the mechanism of this effect. The effects of mianserin in vivo and in vitro were compared with those of trifluoromethylphenylpiperazine (TFPP), a directly… CONTINUE READING
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