Adaptive changes in amino acid metabolism permit normal longevity in mice consuming a low-carbohydrate ketogenic diet.

  title={Adaptive changes in amino acid metabolism permit normal longevity in mice consuming a low-carbohydrate ketogenic diet.},
  author={N. Douris and Tamar Melman and Jordan M Pecherer and P. Pissios and J. Flier and L. Cantley and J. Locasale and E. Maratos-Flier},
  journal={Biochimica et biophysica acta},
  volume={1852 10 Pt A},
  • N. Douris, Tamar Melman, +5 authors E. Maratos-Flier
  • Published 2015
  • Biology, Medicine
  • Biochimica et biophysica acta
  • Ingestion of very low-carbohydrate ketogenic diets (KD) is associated with weight loss, lowering of glucose and insulin levels and improved systemic insulin sensitivity. However, the beneficial effects of long-term feeding have been the subject of debate. We therefore studied the effects of lifelong consumption of this diet in mice. Complete metabolic analyses were performed after 8 and 80weeks on the diet. In addition we performed a serum metabolomic analysis and examined hepatic gene… CONTINUE READING
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