Adaptive changes in amino acid metabolism permit normal longevity in mice consuming a low-carbohydrate ketogenic diet.

@article{Douris2015AdaptiveCI,
  title={Adaptive changes in amino acid metabolism permit normal longevity in mice consuming a low-carbohydrate ketogenic diet.},
  author={Nicholas Douris and Tamar Melman and Jordan M Pecherer and Pavlos Pissios and Jeffrey S. Flier and Lewis C. Cantley and Jason W. Locasale and Eleftheria Maratos-Flier},
  journal={Biochimica et biophysica acta},
  year={2015},
  volume={1852 10 Pt A},
  pages={
          2056-65
        }
}
Ingestion of very low-carbohydrate ketogenic diets (KD) is associated with weight loss, lowering of glucose and insulin levels and improved systemic insulin sensitivity. However, the beneficial effects of long-term feeding have been the subject of debate. We therefore studied the effects of lifelong consumption of this diet in mice. Complete metabolic analyses were performed after 8 and 80weeks on the diet. In addition we performed a serum metabolomic analysis and examined hepatic gene… CONTINUE READING
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