Adaptive and maladaptive psychobiological responses to severe psychological stress: implications for the discovery of novel pharmacotherapy

  title={Adaptive and maladaptive psychobiological responses to severe psychological stress: implications for the discovery of novel pharmacotherapy},
  author={O. Bonne and Christian Grillon and Meena Vythilingam and Alexander Neumeister and Dennis S. Charney},
  journal={Neuroscience \& Biobehavioral Reviews},
PTSD and stress sensitisation: A tale of brain and body Part 2: Animal models
  • R. Stam
  • Psychology, Biology
    Neuroscience & Biobehavioral Reviews
  • 2007
The long‐term costs of traumatic stress: intertwined physical and psychological consequences
  • A. McFarlane
  • Psychology, Medicine
    World psychiatry : official journal of the World Psychiatric Association
  • 2010
An increasing body of literature suggests that the effects of traumatic stress need to be considered as a major environmental challenge that places individual's physical and psychological health equally at risk.
Changes in Galanin Systems in a Rat Model of Post-Traumatic Stress Disorder (PTSD)
Investigation of how Gal expression changes in the brain of rats 2 weeks after exposure to footshock found differential regulation (dysregulation) of the neuropeptide Gal in these tissues may contribute to anxiety and PTSD development.
Neuropsychological Assessment of Posttraumatic Stress Disorder (PTSD)
This chapter will focus on PTSD as a neurobehavioral syndrome, including a brief review of its clinical presentation and underlying neuropathology, and key clinical considerations in conducting neuropsychological evaluations when PTSD is a possible diagnosis.
The psychobiology of depression and resilience to stress: implications for prevention and treatment.
Potential psychological, social, spiritual, and neurobiological approaches to enhancing stress resilience, decreasing the likelihood of developing stress- induced depression/anxiety, and treating stress-induced psychopathology are discussed.
Establishing an Agenda for Translational Research on PTSD
New data indicate that a single stress episode can cause a delayed alteration in synapse formation in the basolateral amygdala without changing dendritic length and branching, which may tell how the brain is shaped by acute and repeated uncontrollable stress in ways that can be investigated in human anxiety disorders.
PTSD: From Neurons to Networks
Findings from various rodent models of stress are summarized, focusing on the morphological, electrophysiological, endocrine and molecular effects of stress in the hippocampus, amygdala, and prefrontal cortex.


Psychophysiological alterations in post-traumatic stress disorder.
Electroencephalographic event-related potential (ERP) response abnormalities in PTSD include reduced P2 amplitude at high stimulus intensities, impaired P1 habituation, and attenuated P3 amplitude to target auditory stimuli.
Psychophysiological assessment: clinical applications for PTSD.
A neuropsychological hypothesis explaining posttraumatic stress disorders.
  • L. Kolb
  • Psychology, Biology
    The American journal of psychiatry
  • 1987
The author postulates that the "constant" symptoms of the disorder are due to the changes in the agonistic neuronal system which impair cortical control of hindbrain structures concerned with aggressive expression and the sleep-dream cycle.
Glutamate and post-traumatic stress disorder: toward a psychobiology of dissociation.
The therapeutic and neuroprotective potential of drugs that attenuate glutamate release should be explored in traumatized individuals with dissociative symptoms.
A prospective study of psychophysiological arousal, acute stress disorder, and posttraumatic stress disorder.
This study investigated the role of acute arousal in the development of posttraumatic stress disorder (PTSD) and found that participants who developed PTSD had higher HR in the acute posttrauma phase than those without PTSD.
Sensitization components of post-traumatic stress disorder: implications for therapeutics.
Suggestions are made for differential strategies of therapeutic intervention as primary prevention, in the immediate post- traumatic period, and in the late phases of post-traumatic stress disorder evolution.