Adaptive amphiphilic dendrimer-based nanoassemblies as robust and versatile siRNA delivery systems.

Abstract

siRNA delivery remains a major challenge in RNAi-based therapy. Here, we report for the first time that an amphiphilic dendrimer is able to self-assemble into adaptive supramolecular assemblies upon interaction with siRNA, and effectively delivers siRNAs to various cell lines, including human primary and stem cells, thereby outperforming the currently available nonviral vectors. In addition, this amphiphilic dendrimer is able to harness the advantageous features of both polymer and lipid vectors and hence promotes effective siRNA delivery. Our study demonstrates for the first time that dendrimer-based adaptive supramolecular assemblies represent novel and versatile means for functional siRNA delivery, heralding a new age of dendrimer-based self-assembled drug delivery in biomedical applications.

DOI: 10.1002/anie.201406764

5 Figures and Tables

Cite this paper

@article{Liu2014AdaptiveAD, title={Adaptive amphiphilic dendrimer-based nanoassemblies as robust and versatile siRNA delivery systems.}, author={Xiaoxuan Liu and Jiehua Zhou and Tianzhu Yu and Chao Chen and Qiang Cheng and Kheya Sengupta and Yuanyu Huang and Haitang Li and Cheng Chih Liu and Yang Wang and Paola Posocco and Menghua Wang and Qi Cui and Suzanne Giorgio and Maurizio Fermeglia and Fanqi Qu and Sabrina Pricl and Yan-hong Shi and Zicai Liang and Palma Rocchi and John Rossi and Ling Peng}, journal={Angewandte Chemie}, year={2014}, volume={53 44}, pages={11822-7} }