Adaptive Immunity: Care for the community

  title={Adaptive Immunity: Care for the community},
  author={M. McFall-Ngai},
A memory-based immune system may have evolved in vertebrates because of the need to recognize and manage complex communities of beneficial microbes. 
Why study the evolution of immunity?
Investigations of immune recognition in nonmammalian species provide new insights into the evolution of immunity and the inner workings of the mammalian immune system. Very diverse mechanisms areExpand
The Evolution of Mutualism in Gut Microbiota Via Host Epithelial Selection
A computer model of the gut shows how a host can readily select friendly bacteria over harmful bacteria through a process called “selectivity amplification.”
A Common Origin for Immunity and Digestion
A common origin is proposed for both the digestive and immune systems, which provides a new prism for viewing the emergence and evolution of host defense mechanisms. Expand
Immune function keeps endosymbionts under control
Evidence is provided that the mutualism between a beetle and its bacterial endosymbiont could be mediated through the expression of host immune genes. Expand
Why does the immune system of Atlantic cod lack MHC II?
  • B. Star, S. Jentoft
  • Biology, Medicine
  • BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2012
MHC II, a major feature of the adaptive immune system, is lacking in Atlantic cod, and there are different scenarios (metabolic cost hypothesis or functional shift hypothesis) that might explain thisExpand
Commentary on: “A common origin for immunity and digestion”
Commentary on a common origin for immunity and digestion in animals and humans and its role in infectious disease is provided by Van Niekerk, G. & Engelbrecht, A. M. Expand
Interplay between the TH17 and TReg cell lineages: a (co-)evolutionary perspective
It is speculated that the co-evolution of these adaptive immune pathways might have given primitive vertebrates a means to benefit from the diversification of their commensal microbiota. Expand
Towards a General Theory of Immunity?
It is believed that the immune system will be increasingly understood as a central component of a network of partner physiological systems that interconnect to maintain homeostasis. Expand