Adaptive Immune-like γ/δ T Lymphocytes Share Many Common Features with Their α/β T Cell Counterparts.

@article{Lombs2015AdaptiveI,
  title={Adaptive Immune-like γ/δ T Lymphocytes Share Many Common Features with Their α/β T Cell Counterparts.},
  author={Am{\'e}lie Lomb{\`e}s and Aur{\'e}lie Durand and C{\'e}line Charvet and Matthieu Rivi{\`e}re and Nelly Bonilla and C{\'e}dric Auffray and Bruno Lucas and Bruno Martin},
  journal={Journal of immunology},
  year={2015},
  volume={195 4},
  pages={1449-58}
}
To better apprehend γ/δ T cell biological functions in the periphery, it appears crucial to identify markers highlighting the existence of distinct phenotypic and functional γ/δ T cell subsets. Interestingly, the expression of CD44 and Ly-6C subdivides murine peripheral γ/δ T cells into several subsets, with Ly-6C(-) CD44(hi) γ/δ T cells corresponding to the IL-17-producing CD27(-) γ/δ T cell subset exhibiting innate-like features. By comparing the other subsets to naive and memory CD8(+) α/β T… CONTINUE READING