Adaptive Immune Responses in CNS Autoimmune Disease: Mechanisms and Therapeutic Opportunities

@article{McPherson2013AdaptiveIR,
  title={Adaptive Immune Responses in CNS Autoimmune Disease: Mechanisms and Therapeutic Opportunities},
  author={Rhoanne C. McPherson and Stephen Anderton},
  journal={Journal of Neuroimmune Pharmacology},
  year={2013},
  volume={8},
  pages={774-790}
}
The processes underlying autoimmune CNS inflammation are complex, but key roles for autoimmune lymphocytes seem inevitable, based on clinical investigations in multiple sclerosis (MS) and related diseases such as neuromyelitis optica, together with the known pathogenic activity of T cells in experimental autoimmune encephalomyelitis (EAE) models. Despite intense investigation, the details of etiopathology in these diseases have been elusive. Here we describe recent advances in the rodent models… 

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