Adaptive Evolution of Toll-Like Receptors (TLRs) in the Family Suidae

@inproceedings{DarfourOduro2015AdaptiveEO,
  title={Adaptive Evolution of Toll-Like Receptors (TLRs) in the Family Suidae},
  author={Kwame A. Darfour-Oduro and Hendrik-Jan Megens and Alfred L Roca and Martien A M Groenen and Lawrence B. Schook},
  booktitle={PloS one},
  year={2015}
}
Members of the family Suidae have diverged over extended evolutionary periods in diverse environments, suggesting that adaptation in response to endemic infectious agents may have occurred. Toll-like receptors (TLRs) comprise a multigene family that acts as the first line of defense against infectious microbes at the host-environment interface. We hypothesized that across the Suidae, positive selection mediated by infectious agents has contributed to the evolution of TLR diversity. Thus, we… CONTINUE READING
4 Citations
55 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 55 references

Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist

  • HM Kim, BS Park, J-I Kim, SE Kim, J Lee, SC Oh
  • Eritoran. Cell
  • 2007
Highly Influential
4 Excerpts

Order Artiodactyla

  • P. Grubb
  • 2005
Highly Influential
5 Excerpts

Similar Papers

Loading similar papers…