Adaptive Evolution of Toll-Like Receptors (TLRs) in the Family Suidae

  title={Adaptive Evolution of Toll-Like Receptors (TLRs) in the Family Suidae},
  author={Kwame A. Darfour-Oduro and Hendrik-Jan Megens and Alfred L Roca and Martien A M Groenen and Lawrence B. Schook},
  booktitle={PloS one},
Members of the family Suidae have diverged over extended evolutionary periods in diverse environments, suggesting that adaptation in response to endemic infectious agents may have occurred. Toll-like receptors (TLRs) comprise a multigene family that acts as the first line of defense against infectious microbes at the host-environment interface. We hypothesized that across the Suidae, positive selection mediated by infectious agents has contributed to the evolution of TLR diversity. Thus, we… CONTINUE READING
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