Adaptive Evolution of Conserved Noncoding Elements in Mammals

  title={Adaptive Evolution of Conserved Noncoding Elements in Mammals},
  author={Su Yeon Kim and Jonathan K. Pritchard},
  journal={PLoS Genetics},
  pages={107 - 116}
Conserved noncoding elements (CNCs) are an abundant feature of vertebrate genomes. Some CNCs have been shown to act as cis-regulatory modules, but the function of most CNCs remains unclear. To study the evolution of CNCs, we have developed a statistical method called the "shared rates test" to identify CNCs that show significant variation in substitution rates across branches of a phylogenetic tree. We report an application of this method to alignments of 98,910 CNCs from the human, chimpanzee… CONTINUE READING
46 Citations
56 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 46 extracted citations


Publications referenced by this paper.
Showing 1-10 of 56 references

Similar Papers

Loading similar papers…