Adaptive Evolution of Conserved Noncoding Elements in Mammals

@article{Kim2007AdaptiveEO,
  title={Adaptive Evolution of Conserved Noncoding Elements in Mammals},
  author={Su Yeon Kim and Jonathan K. Pritchard},
  journal={PLoS Genetics},
  year={2007},
  volume={3},
  pages={107 - 116}
}
Conserved noncoding elements (CNCs) are an abundant feature of vertebrate genomes. Some CNCs have been shown to act as cis-regulatory modules, but the function of most CNCs remains unclear. To study the evolution of CNCs, we have developed a statistical method called the "shared rates test" to identify CNCs that show significant variation in substitution rates across branches of a phylogenetic tree. We report an application of this method to alignments of 98,910 CNCs from the human, chimpanzee… CONTINUE READING
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