Adaptive Clinical Trials

  title={Adaptive Clinical Trials},
  author={C. Coffey and John A. Kairalla},
  journal={Drugs in R & D},
  • C. Coffey, John A. Kairalla
  • Published 2008
  • Medicine
  • Drugs in R & D
  • Adaptive designs promise the flexibility to redesign clinical trials at interim stages. This flexibility would provide greater efficiency in drug development. However, despite this promise, many hesitate to implement such designs. Here we explore three possible reasons for the hesitation: (i) confusion with respect to the definition of an ‘adaptive design’ (ii) controversy surrounding the use of sample size re-estimation methods; and (iii) logistical barriers that must be overcome in order to… CONTINUE READING
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