• DOI:10.2165/00126839-200809040-00003
Corpus ID: 11861515

Adaptive Clinical Trials

@article{Coffey2008AdaptiveCT,
  title={Adaptive Clinical Trials},
  author={C. Coffey and John A. Kairalla},
  journal={Drugs in R & D},
  year={2008},
  volume={9},
  pages={229-242}
}

C. Coffey, John A. Kairalla

Published 2008

Medicine

Drugs in R & D

Adaptive designs promise the flexibility to redesign clinical trials at interim stages. This flexibility would provide greater efficiency in drug development. However, despite this promise, many hesitate to implement such designs. Here we explore three possible reasons for the hesitation: (i) confusion with respect to the definition of an ‘adaptive design’ (ii) controversy surrounding the use of sample size re-estimation methods; and (iii) logistical barriers that must be overcome in order to… CONTINUE READING

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