Adaptive Clinical Trials

@article{Coffey2008AdaptiveCT,
  title={Adaptive Clinical Trials},
  author={C. Coffey and John A. Kairalla},
  journal={Drugs in R & D},
  year={2008},
  volume={9},
  pages={229-242}
}
  • C. Coffey, John A. Kairalla
  • Published 2008
  • Medicine
  • Drugs in R & D
  • Adaptive designs promise the flexibility to redesign clinical trials at interim stages. This flexibility would provide greater efficiency in drug development. However, despite this promise, many hesitate to implement such designs. Here we explore three possible reasons for the hesitation: (i) confusion with respect to the definition of an ‘adaptive design’ (ii) controversy surrounding the use of sample size re-estimation methods; and (iii) logistical barriers that must be overcome in order to… CONTINUE READING
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    References

    SHOWING 1-10 OF 96 REFERENCES
    Self-designing clinical trials.
    • L. Fisher
    • Computer Science, Medicine
    • Statistics in medicine
    • 1998
    • 223
    A regulatory view on adaptive/flexible clinical trial design.
    • 69
    The role of internal pilot studies in increasing the efficiency of clinical trials.
    • 388
    Mid-trial design reviews for sequential clinical trials.
    • 46
    Combining different phases in the development of medical treatments within a single trial.
    • 244