Adaptive Bolus-Based Set-Point Regulation of Hyperglycemia in Critical Care

@article{Lin2004AdaptiveBS,
  title={Adaptive Bolus-Based Set-Point Regulation of Hyperglycemia in Critical Care},
  author={Jeen-Fong Lin and J. Geo rey Chase and G Shaw and C. V. Doran and C. E. Hann and M. B. Robertson and P. M. Browne and T. Lotz and G Wake and Bob Broughton},
  journal={The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society},
  year={2004},
  volume={2},
  pages={3463-3466}
}
Critically ill patients are often hyperglycemic and extremely diverse in their dynamics. Consequently, fixed protocols and sliding scales can result in error and poor control. A two-compartment glucose-insulin system model that accounts for time-varying insulin sensitivity and endogenous glucose removal, along with two different saturation kinetics is developed and verified in proof-of-concept clinical trials for adaptive control of hyperglycemia. The adaptive control algorithm monitors the… CONTINUE READING
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