Adaptive Amplification An Inducible Chromosomal Instability Mechanism

@article{Hastings2000AdaptiveAA,
  title={Adaptive Amplification An Inducible Chromosomal Instability Mechanism},
  author={P J Hastings and Harold J Bull and Jennifer R Klump and Susan M Rosenberg},
  journal={Cell},
  year={2000},
  volume={103},
  pages={723-731}
}
Adaptive mutation is an induced response to environmental stress in which mutation rates rise, producing permanent genetic changes that can adapt cells to stress. This contrasts with neo-Darwinian views of genetic change rates blind to environmental conditions. DNA amplification is a flexible, reversible genomic change that has long been postulated to be adaptive. We report the discovery of adaptive amplification at the lac operon in Escherichia coli. Additionally, we find that adaptive… CONTINUE READING

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