Adaptive Activation of a Stress Response Pathway Improves Learning and Memory Through Gs and β-Arrestin-1–Regulated Lactate Metabolism

@article{Dong2017AdaptiveAO,
  title={Adaptive Activation of a Stress Response Pathway Improves Learning and Memory Through Gs and β-Arrestin-1–Regulated Lactate Metabolism},
  author={Jun-hong Dong and Yi-jing Wang and Min Cui and Xiao-Jing Wang and Jin-peng Sun},
  journal={Biological Psychiatry},
  year={2017},
  volume={81},
  pages={654-670}
}
BACKGROUND Stress is a conserved physiological response in mammals. Whereas moderate stress strengthens memory to improve reactions to previously experienced difficult situations, too much stress is harmful. METHODS We used specific β-adrenergic agonists, as well as β2-adrenergic receptor (β2AR) and arrestin knockout models, to study the effects of adaptive β2AR activation on cognitive function using Morris water maze and object recognition experiments. We used molecular and cell biological… CONTINUE READING
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