Adapting a transforming growth factor beta-related tumor protection strategy to enhance antitumor immunity.

@article{Bollard2002AdaptingAT,
  title={Adapting a transforming growth factor beta-related tumor protection strategy to enhance antitumor immunity.},
  author={Catherine M. Bollard and C. R{\"o}ssig and Mar{\'i}a Julia Calonge and M. Helen Huls and H. Wagner and Joan Massagu{\'e} and Malcolm K. Brenner and Helen E Heslop and Cliona M Rooney},
  journal={Blood},
  year={2002},
  volume={99 9},
  pages={3179-87}
}
Transforming growth factor beta (TGF-beta), a pleiotropic cytokine that regulates cell growth and differentiation, is secreted by many human tumors and markedly inhibits tumor-specific cellular immunity. Tumors can avoid the differentiating and apoptotic effects of TGF-beta by expressing a nonfunctional TGF-beta receptor. We have determined whether this immune evasion strategy can be manipulated to shield tumor-specific cytotoxic T lymphocytes (CTLs) from the inhibitory effects of tumor-derived… CONTINUE READING

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Cytotoxic T lymphocyte therapy for EBV Hodgkin disease

C Bollard, B Gahn, L Aguilar
[abstract]. Blood • 2000

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