Adapter function of protein-tyrosine phosphatase 1D in insulin receptor/insulin receptor substrate-1 interaction.

@article{Kharitonenkov1995AdapterFO,
  title={Adapter function of protein-tyrosine phosphatase 1D in insulin receptor/insulin receptor substrate-1 interaction.},
  author={Alexei Kharitonenkov and Juergen Schnekenburger and Zhongqing Chen and Pjotr G. Knyazev and Suhad A. Ali and Esther Zwick and Morris F.WhiteM.F. White and Axel Prof Dr Ullrich},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 49},
  pages={
          29189-93
        }
}
Insulin signal transduction involves the multisite docking protein insulin receptor substrate-1 (IRS-1) and a number of Src homology-2 (SH2) domain factors, including p85/p110 phosphatidylinositol 3-kinase, p110 GTPase-activating protein, and the phosphotyrosine-specific phosphatase PTP1D. In transfected baby hamster kidney cells, Rat1 fibroblasts, and normal IM9 lymphoblasts, PTP1D directly binds activated insulin receptor. This interaction is mediated by catalytic domain-proximal SH2… CONTINUE READING

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