Adaptations of vertebrate neurons to hypoxia and anoxia: maintaining critical Ca2+ concentrations.

@article{Bickler1998AdaptationsOV,
  title={Adaptations of vertebrate neurons to hypoxia and anoxia: maintaining critical Ca2+ concentrations.},
  author={Philip E. Bickler and Leslie Thomas Buck},
  journal={The Journal of experimental biology},
  year={1998},
  volume={201 Pt 8},
  pages={1141-52}
}
Down-regulation of ion channel activity ('channel arrest'), which aids in preserving critical ion gradients in concert with greatly diminished energy production, is one important strategy by which anoxia-tolerant neurons adapt to O2 shortage. Channel arrest results in the elimination of action potentials and neurotransmission and also decreases the need for ion transport, which normally requires a large energy expenditure. Important targets of this down-regulation may be channels in which… CONTINUE READING

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