Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC‐1

@article{Baar2002AdaptationsOS,
  title={Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC‐1},
  author={K. Baar and A. Wende and T. E. Jones and Matthew Marison and L. Nolte and May M. Chen and D. Kelly and J. Holloszy},
  journal={The FASEB Journal},
  year={2002},
  volume={16},
  pages={1879 - 1886}
}
Endurance exercise induces increases in mitochondria and the GLUT4 isoform of the glucose transporter in muscle. Although little is known about the mechanisms underlying these adaptations, new information has accumulated regarding how mitochondrial biogenesis and GLUT4 expression are regulated. This includes the findings that the transcriptional coactivator PGC‐1 promotes mitochondrial biogenesis and that NRF‐1 and NRF‐2 act as transcriptional activators of genes encoding mitochondrial enzymes… Expand
Exercise-induced Mitochondrial Biogenesis Begins before the Increase in Muscle PGC-1α Expression*
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It appears that activation of PGC-1α may mediate the initial phase of the exercise-induced adaptive increase in muscle mitochondria, whereas the subsequent increase in P GC-1 α protein sustains and enhances the increase in mitochondrial biogenesis. Expand
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Regulation of mitochondrial biogenesis and GLUT4 expression by exercise.
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  • Biology, Medicine
  • Comprehensive Physiology
  • 2011
TLDR
This review describes what is known regarding the regulation of mitochondrial biogenesis and GLUT4 expression by exercise and deals with the physiological and metabolic consequences of the exercise-induced increase in mitochondria andGLUT4. Expand
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  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
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TLDR
An overview of what is known regarding mitochondrial biogenesis and exercise is presented to present an overview of the mechanisms by which these phenomena are regulated. Expand
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  • Clinical and experimental pharmacology & physiology
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TLDR
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Symposium 3 : Mechanisms involved in exercise-induced mitochondrial biogenesis in skeletal muscle Involvement of PPAR g coactivator-1 , nuclear respiratory factors 1 and 2 , and PPAR a in the adaptive response to endurance exercise
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Role of PGC-1α signaling in skeletal muscle health and disease
  • C. Kang, Li Li Ji
  • Biology, Medicine
  • Annals of the New York Academy of Sciences
  • 2012
TLDR
PGC‐1α appears to play a protective role against atrophy‐linked skeletal muscle deterioration and upregulating nuclear respiratory factors and mitochondrial transcription factor A leads to increased mitochondrial DNA replication and gene transcription. Expand
PGC-1 isoforms and their target genes are expressed differently in human skeletal muscle following resistance and endurance exercise
TLDR
PGC‐1 transcripts in human skeletal muscle were comprehensively assayed and showed exercise mode‐specific responses thus improving the understanding of early signaling events in exercise‐induced muscle adaptations. Expand
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