Adaptations of skeletal muscle to endurance exercise and their metabolic consequences.

@article{Holloszy1984AdaptationsOS,
  title={Adaptations of skeletal muscle to endurance exercise and their metabolic consequences.},
  author={J. Holloszy and E. Coyle},
  journal={Journal of applied physiology: respiratory, environmental and exercise physiology},
  year={1984},
  volume={56 4},
  pages={
          831-8
        }
}
  • J. Holloszy, E. Coyle
  • Published 1984
  • Medicine
  • Journal of applied physiology: respiratory, environmental and exercise physiology
Regularly performed endurance exercise induces major adaptations in skeletal muscle. These include increases in the mitochondrial content and respiratory capacity of the muscle fibers. As a consequence of the increase in mitochondria, exercise of the same intensity results in a disturbance in homeostasis that is smaller in trained than in untrained muscles. The major metabolic consequences of the adaptations of muscle to endurance exercise are a slower utilization of muscle glycogen and blood… Expand
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References

SHOWING 1-10 OF 66 REFERENCES
PHYSIOLOGICAL CONSEQUENCES OF THE BIOCHEMICAL ADAPTATIONS TO ENDURANCE EXERCISE *
The adaptations to endurance exercise in skeletal muscle and in the heart have been reviewed in detail recently 1 2 and will therefore be summarized only briefly here to provide a background for aExpand
Skeletal muscle respiratory capacity, endurance, and glycogen utilization.
TLDR
There were significant correlations between the levels of three mitochondrial markers in the animals' gastrocnemius muscles and the duration of a run to exhaustion, and these findings are compatible with the interpretation that a close relationshiop exists between skeletal muscle mitochondrial content and the capacity to perform endurance exercise. Expand
Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle.
  • J. Holloszy
  • Biology, Medicine
  • The Journal of biological chemistry
  • 1967
TLDR
The increase in electron transport capacity was associated with a concomitant rise in the capacity to produce adenosine triphosphate, which may partially account for the increase in aerobic work capacity that occurs with regularly performed, prolonged exercise. Expand
Lipid metabolism in skeletal muscle of endurance-trained males and females.
TLDR
Data support the concept that endurance training markedly enhances the capacity of muscles to metabolize fats, and the factors that regulate the usage of lipids during prolonged exercise do not appear to be limited by thecapacity of the fibers to oxidize fatty acids, as determined by in vitro measurements. Expand
Biochemical adaptation of mitochondria, muscle, and whole-animal respiration to endurance training.
TLDR
Comparison of O2 consumption at the mitochondrial, muscle, and whole-animal levels revealed that maximal muscle oxidase activity was not an absolute limitation to VO2max, and it was concluded that other factors intervene to control the percentage of muscle O 2 consumption capacity which may be utilized during exercise. Expand
Biochemical adaptations in muscle. II. Response of mitochondrial adenosine triphosphatase, creatine phosphokinase, and adenylate kinase activities in skeletal muscle to exercise.
TLDR
Evidence is provided that endurance exercise results in an adaptive increase in the capacity of muscle to regenerate ATP aerobically, whereas the ability to form ATP by anaerobic mechanisms is unaffected. Expand
EFFECTS OF LONG-TERM EXERCISE ON HUMAN MUSCLE MITOCHONDRIA
TLDR
Further evidence is presented that exercise training in man stimulates mitochondrial growth, oxidative capacity, and capacity for syntheses of glycogen and lipid. Expand
Influence of exercise intensity and duration on biochemical adaptations in skeletal muscle.
The influence of intensity and daily duration of exercise on cytochrome c concentration in the three muscle fiber types was assessed in rats that were treadmill trained for 8 wk (5 days/wk) by 1 ofExpand
The effect of exercise on skeletal muscle fibres
TLDR
The duration of the exercise was found to be important in producing fibre hypertrophy than the intensity, while short duration exercise caused significant hypotrophy and swimming exercises caused no significant changes in fibre diameter. Expand
Training induced adaptation of skeletal muscle and metabolism during submaximal exercise
TLDR
After the training period, muscle oxidative capacity, determined as succinate dehydrogenase activity, was 27% higher in the trained (as opposed to the control) leg (P < 0·05). Expand
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