Adaptational "crosstalk" and the crucial role of methylation in chemotactic migration by Escherichia coli.

@article{Hazelbauer1989AdaptationalA,
  title={Adaptational "crosstalk" and the crucial role of methylation in chemotactic migration by Escherichia coli.},
  author={Gerald L. Hazelbauer and Chankyu Park and Dawn M. Nowlin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1989},
  volume={86 5},
  pages={1448-52}
}
We investigated roles of methylation in bacterial chemotaxis by characterizing a methyl-accepting transducer protein incapable of methylation because of amino acid substitutions at the modification sites. Mutant Trg protein recognized ligand and generated excitatory signals that affected flagella but was unable to mediate efficient adaptation or net cellular migration in a relevant chemical gradient. Defects caused by lack of methyl-accepting sites on Trg were suppressed by a sufficient… CONTINUE READING

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