Adaptation to hypoxia and acidosis in carcinogenesis and tumor progression.

@article{Fang2008AdaptationTH,
  title={Adaptation to hypoxia and acidosis in carcinogenesis and tumor progression.},
  author={Jennifer Shea-Ying Fang and Robert D Gillies and Robert A. Gatenby},
  journal={Seminars in cancer biology},
  year={2008},
  volume={18 5},
  pages={330-7}
}
Carcinogenesis is a complex, multistep, multipath process often described as "somatic evolution". Conventional models of cancer progression are typically based on the genetic and epigenetic changes observed in malignant and premalignant tumors. We have explored an alternative approach that emphasizes the selection forces within adaptive landscapes governing growth and evolution in in situ, microinvasive, and metastatic cancers. In each environment, specific barriers to proliferation act as… CONTINUE READING