Adaptation to hypoxia alters energy metabolism in rat heart.

  title={Adaptation to hypoxia alters energy metabolism in rat heart.},
  author={William L Rumsey and B Abbott and Darci Bertelsen and M Mallamaci and K Hagan and D Nelson and M Erecinska},
  journal={The American journal of physiology},
  volume={276 1 Pt 2},
  • William L Rumsey, B Abbott, +4 authors M Erecinska
  • Published 1999 in The American journal of physiology
The present study characterized metabolic changes in the heart associated with long-term exposure to hypoxia, a potent stimulus for pulmonary hypertension and right ventricular hypertrophy. When anesthetized rats adapted to chronic hypoxia spontaneously respired room air, their mean right intraventricular peak systolic pressure (RVSP) was twice that in normal control animals with the same arterial PO2. RVSP was linearly related to right ventricular mass (r = 0.78). Oxidative capacity (O2… CONTINUE READING