Adaptation to chronic MG132 reduces oxidative toxicity by a CuZnSOD-dependent mechanism.

@article{Leak2008AdaptationTC,
  title={Adaptation to chronic MG132 reduces oxidative toxicity by a CuZnSOD-dependent mechanism.},
  author={Rehana K Leak and Michael J. Zigmond and Anthony K. F. Liou},
  journal={Journal of neurochemistry},
  year={2008},
  volume={106 2},
  pages={860-74}
}
To study whether and how cells adapt to chronic cellular stress, we exposed PC12 cells to the proteasome inhibitor MG132 (0.1 microM) for 2 weeks and longer. This treatment reduced chymotrypsin-like proteasome activity by 47% and was associated with protection against both 6-hydroxydopamine (6-OHDA; 100 microM) and higher dose MG132 (40 microM). Protection developed slowly over the course of the first 2 weeks of exposure and was chronic thereafter. There was no change in total GSH levels after… CONTINUE READING