Adaptation to alkylation resistance involves the induction of a DNA glycosylase


Cells exposed to low doses of N-methyl-N′-nitro-N-nitroso-guanidine (MNNG) or methyl methanesulphonate (MMS) acquire resistance to both the mutagenic and lethal effects of a challenging dose of the same agents (ref. 1, and ref. 2 for a review). This response, termed adaptation, has been ascribed to the induced synthesis and accumulation of O-6-methyl… (More)
DOI: 10.1038/296773a0


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