Adaptation to alkalosis induces cell cycle delay and apoptosis in cortical collecting duct cells: role of Aquaporin-2.

@article{Rivarola2010AdaptationTA,
  title={Adaptation to alkalosis induces cell cycle delay and apoptosis in cortical collecting duct cells: role of Aquaporin-2.},
  author={Valeria Rivarola and Pilar Flamenco and Luciana I Melamud and Luciano Galizia and Paula Ford and Claudia Capurro},
  journal={Journal of cellular physiology},
  year={2010},
  volume={224 2},
  pages={405-13}
}
Collecting ducts (CD) not only constitute the final site for regulating urine concentration by increasing apical membrane Aquaporin-2 (AQP2) expression, but are also essential for the control of acid-base status. The aim of this work was to examine, in renal cells, the effects of chronic alkalosis on cell growth/death as well as to define whether AQP2 expression plays any role during this adaptation. Two CD cell lines were used: WT- (not expressing AQPs) and AQP2-RCCD(1) (expressing apical AQP2… CONTINUE READING

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