Adaptation to Human Populations Is Revealed by Within-Host Polymorphisms in HIV-1 and Hepatitis C Virus

@article{Poon2007AdaptationTH,
  title={Adaptation to Human Populations Is Revealed by Within-Host Polymorphisms in HIV-1 and Hepatitis C Virus},
  author={Art F. Y. Poon and Sergei L. Kosakovsky Pond and Phil Bennett and Douglas D. Richman and Andrew J. Leigh Brown and Simon D. W. Frost},
  journal={PLoS Pathogens},
  year={2007},
  volume={3},
  pages={13239 - 13249}
}
CD8(+) cytotoxic T-lymphocytes (CTLs) perform a critical role in the immune control of viral infections, including those caused by human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). As a result, genetic variation at CTL epitopes is strongly influenced by host-specific selection for either escape from the immune response, or reversion due to the replicative costs of escape mutations in the absence of CTL recognition. Under strong CTL-mediated selection, codon positions… CONTINUE READING