Adaptation of the myoglobin knockout mouse to hypoxic stress.

@article{Schlieper2004AdaptationOT,
  title={Adaptation of the myoglobin knockout mouse to hypoxic stress.},
  author={G. Schlieper and J. Kim and A. Molojavyi and C. Jacoby and Tim Laussmann and U. Fl{\"o}gel and A. Goedecke and J. Schrader},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2004},
  volume={286 4},
  pages={
          R786-92
        }
}
  • G. Schlieper, J. Kim, +5 authors J. Schrader
  • Published 2004
  • Medicine, Biology
  • American journal of physiology. Regulatory, integrative and comparative physiology
  • Myoglobin knockout (myo-/-) mice were previously reported to show no obvious phenotype but revealed several compensatory mechanisms that include increases in cardiac capillary density, coronary flow, and hemoglobin. The aim of this study was to investigate whether severe hypoxic stress can exhaust these compensatory mechanisms and whether this can be monitored on the gene and protein level. Myo-/- and wild-type (WT) mice we e exposed to hypoxia (10% O(2)) fo 2 wk. Thereafter hemodynamic… CONTINUE READING
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