Adaptation of the circular platform spatial memory task for mice: use in detecting cognitive impairment in the APP(SW) transgenic mouse model for Alzheimer's disease.

@article{Pompl1999AdaptationOT,
  title={Adaptation of the circular platform spatial memory task for mice: use in detecting cognitive impairment in the APP(SW) transgenic mouse model for Alzheimer's disease.},
  author={Patrick Pompl and Michael J. Mullan and Kimberly B Bjugstad and Gary W. Arendash},
  journal={Journal of neuroscience methods},
  year={1999},
  volume={87 1},
  pages={87-95}
}
A methodology is described for use of a 16-hole circular platform task to test spatial memory in mice. Both bright light and a fan were used to motivate mice to escape the platform surface through a single hole containing an attached escape box. For each daily trial, three correlated measures (escape latency, number of errors, and error rating) comprehensively evaluated cognitive performance. In an initial study, the 'spatial' nature of this task was demonstrated by the much poorer performance… CONTINUE READING

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