Adaptation of muscle glucose transport with caloric restriction in adult, middle-aged, and old rats.

@article{Cartee1994AdaptationOM,
  title={Adaptation of muscle glucose transport with caloric restriction in adult, middle-aged, and old rats.},
  author={Gregory D. Cartee and E W Kietzke and C Briggs-Tung},
  journal={The American journal of physiology},
  year={1994},
  volume={266 5 Pt 2},
  pages={R1443-7}
}
The effects of prolonged caloric restriction (60% of ad libitum intake initiated at 14 wk of age) on glucose transport activity in isolated epitrochlearis muscles were studied in female Fischer 344 rats aged 8, 18, and 23 mo. Basal 3-O-methylglucose transport (3-MG) rate (without insulin) was not significantly altered by caloric restriction. With a submaximally effective insulin concentration (75 microU/ml), 3-MG transport was enhanced in the caloric-restricted groups by 59, 59, and 105% at 8… CONTINUE READING

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