Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis.

@article{Koliaki2015AdaptationOH,
  title={Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis.},
  author={Chrysi Koliaki and Julia Szendroedi and Kirti Kaul and Tomas Jelenik and Peter J. Nowotny and Frank Jankowiak and Christian Herder and Maren Carstensen and Markus Krausch and Wolfram Trudo Knoefel and Matthias Schlensak and Michael Roden},
  journal={Cell metabolism},
  year={2015},
  volume={21 5},
  pages={739-46}
}
The association of hepatic mitochondrial function with insulin resistance and non-alcoholic fatty liver (NAFL) or steatohepatitis (NASH) remains unclear. This study applied high-resolution respirometry to directly quantify mitochondrial respiration in liver biopsies of obese insulin-resistant humans without (n = 18) or with (n = 16) histologically proven NAFL or with NASH (n = 7) compared to lean individuals (n = 12). Despite similar mitochondrial content, obese humans with or without NAFL had… CONTINUE READING
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