Adaptation of an L-Proline Adenylation Domain to Use 4-Propyl-L-Proline in the Evolution of Lincosamide Biosynthesis

Abstract

Clinically used lincosamide antibiotic lincomycin incorporates in its structure 4-propyl-L-proline (PPL), an unusual amino acid, while celesticetin, a less efficient related compound, makes use of proteinogenic L-proline. Biochemical characterization, as well as phylogenetic analysis and homology modelling combined with the molecular dynamics simulation… (More)
DOI: 10.1371/journal.pone.0084902

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@inproceedings{Kadlk2013AdaptationOA, title={Adaptation of an L-Proline Adenylation Domain to Use 4-Propyl-L-Proline in the Evolution of Lincosamide Biosynthesis}, author={Stanislav Kadl{\vc}{\'i}k and Tom{\'a}{\vs} Ku{\vc}era and Dominika Chalupsk{\'a} and Radek Ga{\vz}{\'a}k and Mark{\'e}ta Koběrsk{\'a} and Dana Ulanov{\'a} and J{\'a}n Kopeck{\'y} and Eva Kutějov{\'a} and Lucie Najmanova and Jiri Janata}, booktitle={PloS one}, year={2013} }