Adaptation of a membrane-active peptide to heterogeneous environment. I. Structural plasticity of the peptide.


Some membrane-active peptides undergo drastic changes of conformation and/or orientation on water-lipid interfaces. Among the most notable examples is penetratin (pAntp), a short cell-penetrating peptide. To delineate the driving forces behind pAntp-membrane interactions, we used, in this series of two papers, a combined modeling approach that includes: (1… (More)
DOI: 10.1021/jp803640e


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