Adaptation of a Velogenic Newcastle Disease Virus to Vero Cells: Assessing the Molecular Changes Before and After Adaptation

@article{Mohan2006AdaptationOA,
  title={Adaptation of a Velogenic Newcastle Disease Virus to Vero Cells: Assessing the Molecular Changes Before and After Adaptation},
  author={C. Madhan Mohan and Sohini Dey and Kathaperumal Kumanan and Bhakthavasalam Murali Manohar and A. Mahalinga Nainar},
  journal={Veterinary Research Communications},
  year={2006},
  volume={31},
  pages={371-383}
}
A velogenic Newcastle disease virus isolate was passaged 50 times in Vero cell culture and the virus was assessed for the molecular changes associated with the passaging. At every 10th passage, the virus was characterized conventionally by mean death time (MDT) analysis, intracerebral pathogenicity index (ICPI) and virus titration. At increasing passage… CONTINUE READING