Adaptation of West Nile virus replicons to cells in culture and use of replicon-bearing cells to probe antiviral action.

@article{Rossi2005AdaptationOW,
  title={Adaptation of West Nile virus replicons to cells in culture and use of replicon-bearing cells to probe antiviral action.},
  author={Shannan L. Rossi and Qizu Zhao and Vivian K O'Donnell and Peter W. Mason},
  journal={Virology},
  year={2005},
  volume={331 2},
  pages={457-70}
}
Flaviviruses are emerging threats to public health worldwide. Recently, one flavivirus, West Nile virus (WNV), has caused the largest epidemic of viral encephalitis in US history. Like other flaviviruses, WNV is thought to cause a persistent infection in insect cells, but an acute cytopathic infection of mammalian cells. To study adaptation of WNV to persistently replicate in cell culture and generate a system capable of detecting antiviral compounds in the absence of live virus, we generated… CONTINUE READING

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