Adaptation in patterns of c-fos expression in the brain associated with exposure to either single or repeated social stress in male rats.

@article{Martnez1998AdaptationIP,
  title={Adaptation in patterns of c-fos expression in the brain associated with exposure to either single or repeated social stress in male rats.},
  author={Manuela Herrera Mart{\'i}nez and Patrick J. J. Phillips and Joe Herbert},
  journal={The European journal of neuroscience},
  year={1998},
  volume={10 1},
  pages={
          20-33
        }
}
Intraspecific confrontation between male rats represents a biologically relevant form of social stress. C-fos expression has been used to map the pattern of neural activation following either a single (acute) or repeated (10 times) exposure of an intruder male to a larger male in the latter's home cage. These conditions induce high levels of aggressive interaction. Sixty minutes after a single defeat, there was intense c-fos expression (quantified using image analysis) in restricted areas of… CONTINUE READING

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