Adaptation and survival of surface-deprived red blood cells in mice.

@article{Murdock2000AdaptationAS,
  title={Adaptation and survival of surface-deprived red blood cells in mice.},
  author={Ryan Murdock and Conor C. O. Reynolds and Ingrid H. Sarelius and Richard E. Waugh},
  journal={American journal of physiology. Cell physiology},
  year={2000},
  volume={279 4},
  pages={
          C970-80
        }
}
The consequences of lost membrane area for long-term erythrocyte survival in the circulation were investigated. Mouse red blood cells were treated with lysophosphatidylcholine to reduce membrane area, labeled fluorescently, reinfused into recipient mice, and then sampled periodically for 35 days. The circulating fraction of the modified cells decreased on an approximately exponential time course, with time constants ranging from 2 to 14 days. The ratio of volume to surface area of the surviving… CONTINUE READING

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