Adaptation and Inhibition Control Pathological Synchronization in a Model of Focal Epileptic Seizure

@inproceedings{Buchin2018AdaptationAI,
  title={Adaptation and Inhibition Control Pathological Synchronization in a Model of Focal Epileptic Seizure},
  author={Anatoly Buchin and Cliff C Kerr and Gilles Huberfeld and R. Miles and Boris S. Gutkin},
  booktitle={eNeuro},
  year={2018}
}
Pharmacoresistant epilepsy is a common neurological disorder in which increased neuronal intrinsic excitability and synaptic excitation lead to pathologically synchronous behavior in the brain. In the majority of experimental and theoretical epilepsy models, epilepsy is associated with reduced inhibition in the pathological neural circuits, yet effects of intrinsic excitability are usually not explicitly analyzed. Here we present a novel neural mass model that includes intrinsic excitability in… CONTINUE READING
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