Adaptability and selectivity of human peroxisome proliferator-activated receptor (PPAR) pan agonists revealed from crystal structures

@inproceedings{Oyama2009AdaptabilityAS,
  title={Adaptability and selectivity of human peroxisome proliferator-activated receptor (PPAR) pan agonists revealed from crystal structures},
  author={Takuji Oyama and Kenji Toyota and Tsuyoshi Waku and Yuko Hirakawa and Naoko Nagasawa and Jun-ichi Kasuga and Yuichi Hashimoto and Hiroyuki Miyachi and Kosuke Morikawa},
  booktitle={Acta crystallographica. Section D, Biological crystallography},
  year={2009}
}
Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone receptor family, which is defined as transcriptional factors that are activated by the binding of ligands to their ligand-binding domains (LBDs). Although the three PPAR subtypes display different tissue distribution patterns and distinct pharmacological profiles, they all are essentially related to fatty-acid and glucose metabolism. Since the PPARs share similar three-dimensional structures within the LBDs… CONTINUE READING
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