Adaptability and selectivity of human peroxisome proliferator-activated receptor (PPAR) pan agonists revealed from crystal structures

@article{Oyama2009AdaptabilityAS,
  title={Adaptability and selectivity of human peroxisome proliferator-activated receptor (PPAR) pan agonists revealed from crystal structures},
  author={Takuji Oyama and Kenji Toyota and Tsuyoshi Waku and Yuko Hirakawa and Naoko Nagasawa and Jun-ichi Kasuga and Yuichi Hashimoto and Hiroyuki Miyachi and Kosuke Morikawa},
  journal={Acta Crystallographica Section D: Biological Crystallography},
  year={2009},
  volume={65},
  pages={786 - 795}
}
The structures of the ligand-binding domains (LBDs) of human peroxisome proliferator-activated receptors (PPARα, PPARγ and PPARδ) in complexes with a pan agonist, an α/δ dual agonist and a PPARδ-specific agonist were determined. The results explain how each ligand is recognized by the PPAR LBDs at an atomic level. 
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