Adamantyl-tethered-biphenylic compounds induce apoptosis in cancer cells by targeting Bcl homologs.

  title={Adamantyl-tethered-biphenylic compounds induce apoptosis in cancer cells by targeting Bcl homologs.},
  author={Sebastian Anusha and Chakrabhavi Dhananjaya Mohan and Hanumappa Ananda and C. P. Baburajeev and Shobith Rangappa and Jessin Mathai and Julian E. Fuchs and Feng Li and Muthu Kumaraswamy Shanmugam and Andreas Bender and Gautam Sethi and Basappa and Kanchugarakoppal Subbegowda Rangappa},
  journal={Bioorganic & medicinal chemistry letters},
  volume={26 3},
Bcl homologs prominently contribute to apoptotic resistance in cancer cells and serve as molecular targets in treatment of various cancers. Herein, we report the synthesis of biphenyl-adamantane derivatives by a ligand free palladium on carbon based Suzuki reaction using diisopropylamine as a base for the coupling of adamantane based aryl chloride with a variety of aryl boronic acids. Among the biphenyl derivatives synthesized, compound 3'-(adamantan-1-yl)-4'-methoxy-[1,1'-biphenyl]-3-ol (AMB… CONTINUE READING