Adamantane derivatives of biological interest. Synthesis and antiviral activity of 2-(1-adamantyl)imidazole derivatives.

@article{Pellicciari1981AdamantaneDO,
  title={Adamantane derivatives of biological interest. Synthesis and antiviral activity of 2-(1-adamantyl)imidazole derivatives.},
  author={Roberto Pellicciari and M C Fioretti and Pietro Cogolli and Marcello Tiecco},
  journal={Arzneimittel-Forschung},
  year={1981},
  volume={30 12},
  pages={
          2103-5
        }
}
The methods of synthesis and antiviral evaluation of 2-(1-adamantyl)imidazole (2a), N-methyl-2-(1-adamantyl)imidazole (2b) and 2-(1-adamantyl)benzimidazole (3a) are reported. These compounds are prepared by the selective homolytic substitution reaction by the adamantyl radical (Ad.) on the C-2 carbon atom of the heterocycles. Ad. radicals were generated by oxidative decarboxylation of 1-adamantyl carboxylic acid. Antiviral activities compounds 2a, 2b and 3a were tested in chick embryos against… 
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