Adamantane derivatives: Pharmacological and toxicological properties (review)

@article{Spasov2006AdamantaneDP,
  title={Adamantane derivatives: Pharmacological and toxicological properties (review)},
  author={Alexander A. Spasov and T. V. Khamidova and Lyudmila Bugaeva and I. S. Morozov},
  journal={Pharmaceutical Chemistry Journal},
  year={2006},
  volume={34},
  pages={1-7}
}
Original papers describing the biological properties of adamantane-containing drugs reported on the antiviral activity of 1-aminoadamantane [1]. Presently, the amino derivatives of adamantane are widely used for the prophylaxis and treatment of various viral diseases [2 -4 ] and parkinsonism [5 7]. Six adamantane derivatives are currently used in modem medicine, and two novel preparations have been recently certified. 
Adamantylation of hydantoin
Cage compounds, in particular adamantane derivatives, exhibit a broad spectrum of biological activity [1–9]. Many adamantane derivatives are used as medicines with various therapeutic effects.
Pharmacology and structure‐activity relationships of bioactive polycyclic cage compounds: A focus on pentacycloundecane derivatives
TLDR
The polycyclic cage appears to be a useful scaffold to yield drugs with a wide scope of applications, and can be used also to modify and improve the pharmacokinetic and pharmacodynamic properties of drugs in current use.
In vitro antiproliferative study of novel adamantyl pyridin-4-ones
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It was shown that there was no change in caspase activity in the treated cells, but there were changes in the cell cycle, and LDH cytotoxicity assay revealed that cytotoxic effects occur after 48 h of exposure.
Multifunctional adamantane derivatives as new scaffolds for the multipresentation of bioactive peptides
  • Maxime Grillaud, A. Bianco
  • Chemistry, Biology
    Journal of peptide science : an official publication of the European Peptide Society
  • 2015
TLDR
This review provides a detailed description of the different ways to synthesize multifunctional derivatives starting from adamantane molecule as the main core and describes the interesting biological activity of the diverse multivalent scaffolds, focusing in particular on peptide‐based systems.
Recent advances in therapeutical applications of the versatile hydroxypyridinone chelators
TLDR
This review systematically summarizes the various literature reports on the design and pharmacological activities of the newly developed HOPOs and their derivatives, including antibiotics, anticancer, and antineurodegeneratives.
...
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Behavioral and convulsions studies of the above mentioned amines did not show any dopaminomimetic activity and argue in favor of the existence of a glutamatergic component in the action of these derivatives.
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TLDR
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TLDR
It is concluded that adamantane derivatives bearing an amino group decrease K+ permeability of the β‐cell membrane and thereby cause depolarization, which activates voltage‐dependent Ca channels, permits Ca2+ influx and eventually stimulates insulin release.
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