Adamantane and Nipecotic Acid Derivatives as Novel P-Turn Mimics

@inproceedings{Hoekstra2001AdamantaneAN,
  title={Adamantane and Nipecotic Acid Derivatives as Novel P-Turn Mimics},
  author={William J. Hoekstra and Jeffery B. Press and Mary Pat Bonner and Patricia Andrade-Gordon and Patricia M. Keane and Kathleen A. Durkin},
  year={2001}
}
1,3-Adamantanedhnine and nipecotic acid were. used as scaffolds in designing (hm peptide mimetic de.rivatives 3 and 5. respectively, targeted as fibrinogen-GPIBiIL4 antagonists. The design focused on the 406409 KQAG region of the y-chain of fibrinogen which appears as a p-turn in solution NMR stNctures of Fg-7385-411. As part of our program in… CONTINUE READING