Adam33 polymorphisms are associated with COPD and lung function in long-term tobacco smokers

@article{Sadeghnejad2009Adam33PA,
  title={Adam33 polymorphisms are associated with COPD and lung function in long-term tobacco smokers},
  author={Alireza Sadeghnejad and Jill A. Ohar and S{\'i}qun Lilly Zheng and David A. Sterling and Gregory A Hawkins and Deborah A. Meyers and Eugene Bleecker},
  journal={Respiratory Research},
  year={2009},
  volume={10},
  pages={21 - 21}
}
BACKGROUND Variation in ADAM33 has been shown to be important in the development of asthma and altered lung function. This relationship however, has not been investigated in the population susceptible to COPD; long term tobacco smokers. We evaluated the association between polymorphisms in ADAM33 gene with COPD and lung function in long term tobacco smokers. METHODS Caucasian subjects, at least 50 year old, who smoked >or= 20 pack-years (n = 880) were genotyped for 25 single nucleotide… CONTINUE READING
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