Adalimumab for the treatment of rheumatoid arthritis

@article{Miyasaka2009AdalimumabFT,
  title={Adalimumab for the treatment of rheumatoid arthritis},
  author={Nobuyuki Miyasaka},
  journal={Expert Review of Clinical Immunology},
  year={2009},
  volume={5},
  pages={19 - 26}
}
  • N. Miyasaka
  • Published 2009
  • Medicine
  • Expert Review of Clinical Immunology
Rheumatoid arthritis (RA) is characterized by massive synovial proliferation resulting in joint destruction and deterioration in quality of life. TNF-α has been implicated in the central pathogenesis of RA, and its blockade? by anti-TNF-α monoclonal antibodies (infliximab and adalimumab) and the soluble TNF-α receptor (etanercept) has caused a paradigm shift in the treatment of RA. Adalimumab can be used alone or concomitantly with methotrexate, but the combination of both is significantly… Expand
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References

SHOWING 1-10 OF 49 REFERENCES
Effectiveness of adalimumab for rheumatoid arthritis in patients with a history of TNF-antagonist therapy in clinical practice.
TLDR
In typical clinical practice, adalimumab was effective and well-tolerated in patients with RA previously treated with etanercept and/or infliximab. Expand
Adalimumab alone and in combination with disease-modifying antirheumatic drugs for the treatment of rheumatoid arthritis in clinical practice: the Research in Active Rheumatoid Arthritis (ReAct) trial
TLDR
Considering the limitations of an open-label study, adalimumab alone or in combination with standard DMARDs appeared to be well tolerated and effective in 6610 difficult-to-treat patients with active RA treated in clinical practice. Expand
Radiographic, clinical, and functional outcomes of treatment with adalimumab (a human anti-tumor necrosis factor monoclonal antibody) in patients with active rheumatoid arthritis receiving concomitant methotrexate therapy: a randomized, placebo-controlled, 52-week trial.
TLDR
In this 52-week trial, adalimumab was more effective than placebo at inhibiting the progression of structural joint damage, reducing the signs and symptoms, and improving physical function in patients with active RA who had demonstrated an incomplete response to MTX. Expand
Effects of Abatacept in Patients with Methotrexate-Resistant Active Rheumatoid Arthritis
TLDR
Patients who received abatacept more often had improved physical function, more frequently met standard response criteria, and less often had radiographic progression of joint damage, as well as serious infections and infusion reactions more often. Expand
Adalimumab, a fully human anti-tumor necrosis factor alpha monoclonal antibody, for the treatment of rheumatoid arthritis in patients taking concomitant methotrexate: the ARMADA trial.
TLDR
The addition of adalimumab at a dosage of 20 mg, 40 mg, or 80 mg administered subcutaneously every other week to long-term MTX therapy in patients with active RA provided significant, rapid, and sustained improvement in disease activity over 24 weeks compared with MTX plus placebo. Expand
Efficacy and safety of the fully human anti-tumour necrosis factor alpha monoclonal antibody adalimumab (D2E7) in DMARD refractory patients with rheumatoid arthritis: a 12 week, phase II study.
TLDR
Adalimumab given as monotreatment to patients with longstanding, severe RA refractory to traditional DMARDs produced a rapid, sustained response and was safe and well tolerated, with no dose limiting side effects. Expand
Adalimumab, a fully human anti tumor necrosis factor-alpha monoclonal antibody, and concomitant standard antirheumatic therapy for the treatment of rheumatoid arthritis: results of STAR (Safety Trial of Adalimumab in Rheumatoid Arthritis).
TLDR
The data indicate that adalimumab is a safe and effective therapeutic option in patients with active RA who have an inadequate response to standard antirheumatic therapy, including one or more traditional DMARD, corticosteroids, NSAID, and analgesics. Expand
Clinical response to adalimumab: relationship to anti-adalimumab antibodies and serum adalimumab concentrations in rheumatoid arthritis
TLDR
Serum antibodies against adalimumab are associated with lower serum adalicumab concentrations and non-response to adal optimumab treatment. Expand
Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: a multicenter, double-blind, placebo-controlled trial.
TLDR
Treatment with MRA was generally well tolerated and significantly reduced the disease activity of RA, and the adverse events were not dose dependent. Expand
Tocilizumab for the treatment of rheumatoid arthritis
TLDR
Tocilizumab in combination with methotrexate after 24 weeks of treatment could induce disease remission in 30% of patients with rheumatoid arthritis refractory to anti-TNF antagonist therapy. Expand
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