Adagrasib in Non-Small-Cell Lung Cancer Harboring a KRASG12C Mutation.

  title={Adagrasib in Non-Small-Cell Lung Cancer Harboring a KRASG12C Mutation.},
  author={Pasi A. J{\"a}nne and Gregory Riely and Shirish M. Gadgeel and Rebecca S. Heist and S-H.I. Ou and Jose Maria Pacheco and Melissa L. Johnson and Joshua K. Sabari and Konstantinos Leventakos and Edwin Yau and Lyudmila Bazhenova and Marcelo Vailati Negr{\~a}o and Nathan A. Pennell and Jun Zhang and Kenna Anderes and Hirak Der-Torossian and Thian San Kheoh and Karen Velastegui and Xiao Qiang Yan and James G. Christensen and Richard C. Chao and Alexander I. Spira},
  journal={The New England journal of medicine},
BACKGROUND Adagrasib, a KRASG12C inhibitor, irreversibly and selectively binds KRASG12C, locking it in its inactive state. Adagrasib showed clinical activity and had an acceptable adverse-event profile in the phase 1-1b part of the KRYSTAL-1 phase 1-2 study. METHODS In a registrational phase 2 cohort, we evaluated adagrasib (600 mg orally twice daily) in patients with KRASG12C -mutated non-small-cell lung cancer (NSCLC) previously treated with platinum-based chemotherapy and anti-programmed… 

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