Adacolumn leucocytapheresis for ulcerative colitis: clinical and endoscopic features of responders and unresponders.

@article{Sacco2015AdacolumnLF,
  title={Adacolumn leucocytapheresis for ulcerative colitis: clinical and endoscopic features of responders and unresponders.},
  author={Rodolfo Sacco and Tomotaka Tanaka and Takayuki Yamamoto and Giampaolo Bresci and Abbi R Saniabadi},
  journal={Expert review of gastroenterology & hepatology},
  year={2015},
  volume={9 3},
  pages={
          327-33
        }
}
Cytokines such as TNF-α have a validated role in the immunopathogensis of ulcerative colitis (UC), and intercepting inflammatory cytokines is currently the best option for maximizing treatment efficacy. One of the major sources of inflammatory cytokines are myeloid linage leucocytes (granulocytes, monocytes), which are present in great numbers in the colonic tissue. Their selective depletion by adsorptive granulocyte, monocyte apheresis (GMA), should be therapeutic in patients with UC, although… CONTINUE READING

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  • 2017
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