• Biology
  • Published 2006

AdTGF-β1(上标 223/225)气管内注射制备大鼠肺间质纤维化动物模型

  title={AdTGF-β1(上标 223/225)气管内注射制备大鼠肺间质纤维化动物模型},
  author={李健 and 牛建昭 and 王继峰 and 李彧 and Jack Gauldie and 贲长恩},
Objective To observe histopathological changes of rat model of idiopathic pulmonary fibrosis induced by TGF-β1, gene over-expression. Methods Thirty adult healthy SD rats were randomly divided into 3 groups: blank control group, model group and blank vector control group. Physiological saline 0.4mL, adenovirus-mediated TGF-β1 gene transfer vector (AdTGF-β1(superscript 223/225), 1×l0^9 pfu, 0.4mL) or blank vector (adenovirus without TGF-β1 gene, 1×l0^9 pfu. 0.4mL) were injected into the trachea… CONTINUE READING