Acylcarnitine Chain Length Influences Carnitine‐enhanced Drug Flux through the Spinal Meninges: In Vitro

@article{Ummenhofer1997AcylcarnitineCL,
  title={Acylcarnitine Chain Length Influences Carnitine‐enhanced Drug Flux through the Spinal Meninges: In Vitro},
  author={Wolfgang C. Ummenhofer and Christopher M. Bernards},
  journal={Anesthesiology},
  year={1997},
  volume={86},
  pages={642–648}
}
Background Palmitoyl carnitine has been shown to improve the penetration of hydrophilic drugs through the spinal meninges. Naturally occurring acylcarnitines, however, exist as a homologous series of different acyl chain lengths. The purpose of this study was to determine the most effective acylcarnitine chain length to increase meningeal permeability. Methods The transmeningeal flux of mannitol, morphine, and sufentanil through monkey spinal meninges was determined before and after adding… 

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