Acylation stimulating protein (ASP) deficiency alters postprandial and adipose tissue metabolism in male mice.

@article{Murray1999AcylationSP,
  title={Acylation stimulating protein (ASP) deficiency alters postprandial and adipose tissue metabolism in male mice.},
  author={Ian R. Murray and Allan David Sniderman and P. Havel and Katherine Cianflone},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 51},
  pages={36219-25}
}
Acylation stimulating protein (ASP) is a potent stimulator of triglyceride synthesis in adipocytes. In the present study, we have examined the effect of an ASP functional knockout (ASP(-/-)) on lipid metabolism in male mice. In both young (14 weeks) and older (26 weeks) mice there were marked delays in postprandial triglyceride clearance (80% increase at 14 weeks and 120% increase at 26 weeks versus wild type (+/+)). Postprandial nonesterified fatty acids were also increased in ASP(-/-) mice… CONTINUE READING

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