Acylation of protein lysines by trichloroethylene oxide.

  title={Acylation of protein lysines by trichloroethylene oxide.},
  author={Hui Cai and F Peter Guengerich},
  journal={Chemical research in toxicology},
  volume={13 5},
Stable lysine adducts were formed in proteins following reaction with trichloroethylene (TCE) oxide, the major reactive compound generated by the metabolism of TCE. The order of formation of these adducts is N(6)-formyllysine > N(6)-(dichloroacetyl)lysine >> N(6)-glyoxyllysine, with the ratio being influenced by the particular protein. Protein lysine adducts were also analyzed following the enzymatic oxidation of TCE with several different cytochrome P450 (P450) enzyme systems. The ratio of… CONTINUE READING


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